Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma
نویسندگان
چکیده
منابع مشابه
Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma
Increased levels of the nuclear export protein, exportin 1 (XPO1), were demonstrated in multiple myeloma (MM) patients. Targeting XPO1 with selinexor (the selective inhibitor of nuclear export; SINE compound KPT-330) demonstrates broad antitumor activity also in patient cells resistant to bortezomib; hence, it is a promising target in MM patients. Hypoxia is known to mediate tumor progression a...
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ژورنال
عنوان ژورنال: Translational Oncology
سال: 2017
ISSN: 1936-5233
DOI: 10.1016/j.tranon.2017.04.010